Limiting Retinal Toxicity of Vigabatrin in Children with Infantile Spasms
نویسندگان
چکیده
منابع مشابه
Vigabatrin retinal toxicity in children with infantile spasms
OBJECTIVES To determine time to vigabatrin (VGB, Sabril; Lundbeck, Deerfield, IL) induced retinal damage in children with infantile spasms (IS) and to identify risk factors for VGB-induced retinal damage (VGB-RD). METHODS Observational cohort study including 146 participants (68 female, 81 male) with IS, an age-specific epilepsy syndrome of early infancy, treated with VGB. Participants ranged...
متن کاملReduced grating acuity associated with retinal toxicity in children with infantile spasms on vigabatrin therapy.
PURPOSE To determine whether visual functions are decreased in children with infantile spasms and vigabatrin-attributed retinal toxicity. METHODS Contrast sensitivity and grating acuity were measured by using sweep visual evoked potential (VEP) testing in 42 children with infantile spasms (mean age, 29.23 +/- 18.31 months). All children had been exposed to vigabatrin (VGB) for a minimum of 1 ...
متن کاملThe use of vigabatrin in infantile spasms in Asian children.
BACKGROUND The use of adrenocorticotrophic hormone (ACTH) and prednisolone in the management of infantile spasms has been well established, but is associated with significant morbidity and cannot be used as long-term medication. Since the introduction of vigabatrin, results have been promising with suggestions currently that it should be used as first-line management of infantile spasms. AIM ...
متن کاملVigabatrin versus ACTH in the treatment of infantile spasms.
OBJECTIVE To compare adrenocorticotropic hormone with vigabatrin as a single mono-therapy for infantile spasms. We studied hospitalization time, clinical response, whether complete or partial, time taken for improvement, and presence or absence of recurrence after stopping the medication. Together with improvement of electroencephalographic changes, and time taken for significant response, neur...
متن کاملReduced visual function associated with infantile spasms in children on vigabatrin therapy.
PURPOSE To use visual evoked potential (VEP) testing to determine whether visual deficits are present in children with a history of vigabatrin use. METHODS Contrast sensitivity and visual acuity were assessed by visual evoked potential testing and compared between 28 children (mean age, 4.90 +/- 4.92 years) with seizure disorders who had taken vigabatrin and 14 typically developing children (...
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ژورنال
عنوان ژورنال: Epilepsy Currents
سال: 2015
ISSN: 1535-7597,1535-7511
DOI: 10.5698/1535-7511-15.6.327